E-posters - Broadly neutralizing antibodies

• 1175 • 35O22 and VRC44 Define a New Highly Glycan-Dependent Multidonor Class of HIV-1 gp120:gp41 Interface-Directed bnAbs > E. Evan CALE • 1227 • Precursor Frequencies of naïve B cells targeting HIV candidate immunogens > M. Madhu PRABHAKARAN • 1263 • Low dose administration of unmodified 10E8v4, but not FcγR/complement dual enhanced or dual ablated 10E8v4 variants, decreases viremia in SHIV challenged macaques > D. David SPENCER • 1273 • Functional convergence of clonally related but genetically distinct bNAbs that target the V3-glycan epitope > D. Dale KITCHIN • 1340 • Enhanced Protection at the Site of Challenge of Rhesus Macaques That Receive PGT121 One Week Prior to Intravaginal Challenge With SHIV-SF162P3. > J. Jeffrey SCHNEIDER • 1369 • Functional barriers in the elicitation of broadly neutralizing antibodies against the glycan-V3 site of Env by vaccination > M. Mihai AZOITEI • 1412 • The near-pan-neutralizing, plasma deconvoluted antibody N49P6 mimics CD4 in its quaternary interactions with the HIV-1 envelope trimer > W. William TOLBERT • 1431 • Improved potency, breadth, and pharmacokinetics of VRC01-class antibodies for HIV-1 prevention and treatment > Y. Young Do KWON • 1444 • A lineage of exceptionally potent and broad BnAbs with ultralong CDRH3 from vaccinated cows focus low-mutation rate from germline into a globular knob contacting the CD4bs > N. Natalia SALAZAR QUIROZ • 417 • Structure of a CD4 binding site directed antibody in a donor with broadly neutralizing antibodies > T. Thandeka MOYO • 480 • Next Generation Variants of Super Potent CAP256-VRC26.25 Antibody with Near-Pan HIV-1 Neutralization Breadth > B. Baoshan ZHANG • 532 • Antibody-Antigen Distance of Broadly Neutralizing HIV-1 Antibodies Correlates with Glycan-Shield Coverage of HIV-1 Envelope Trimer > M. Myungjin LEE • 563 • Variation in neutralization susceptibility of HIV-1 Indian Subtype C to potent and broadly neutralizing monoclonal antibodies (bnAbs) having distinct epitope specificities    > N. Nitin HINGANKAR • 579 • Antibody genetic diversity with large structural variation in a South African population > A. Alaine MARSDEN • 660 • Founder Env-specific IgM B cell responses during acute HIV-1 infection associate with the development of broadly neutralizing antibodies > S. Samantha TOWNSLEY • 864 • IgG3 HIV broadly neutralizing antibodies show improved neutralization potency and phagocytosis compared to IgG1 variants > S. Simone RICHARDSON • 884 • Defining the mechanism for varied neutralization potency of HIV neutralizing antibodies with identical variable regions but differing isotype > Z. Zanele MAKHADO