Understanding and unpacking the results of the HPTN 071 (PopART) trial
Thursday, February 4, 2021
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SA19
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12:15 PM
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1:45 PM
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Understanding and unpacking the results of the HPTN 071 (PopART) trial
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Satellite Channel 3
The primary results of the HPTN 071 (PopART) trial were published in July 2019. They showed that the PopART universal testing and treatment (UTT) intervention achieved the UNAIDS 90-90-90 targets within three years, and reduced HIV incidence at population level by about 20%. An unexpected finding was that stronger evidence of an effect on HIV incidence was found in Arm B (where ART was initially delivered according to national guidelines) than in Arm A (where immediate ART was offered throughout the trial). In this symposium, we present a number of additional analyses that have been carried out to gain a clearer understanding of the trial results. We hope that this symposium will help to build a clearer understanding of the results of the trial and their implications.
12:15 PM
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SA19.01
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Introduction: Overview of trial and results
See abstract
12:20 PM
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SA19.02
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Did the PopART intervention lead to changes in sexual behavior? Were there differences in behavior between study arms?
See abstract
12:35 PM
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SA19.03
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Model projections: Did the mathematical model fit the data from the trial? What was the projected impact of the intervention if sustained over time and implemented more widely?
See abstract
12:50 PM
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SA19.04
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How did ART adherence and viral suppression in those on ART compare between study arms and over time? Could poor adherence explain the lower impact in Arm A?
See abstract
1:05 PM
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SA19.05
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What were the community-level correlates of HIV incidence in the trial? Could differences in community viral burden explain the differences in incidence between study arms and between communities?
See abstract
1:20 PM
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SA19.06
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Summary and concluding remarks
See abstract
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