Understanding and unpacking the results of the HPTN 071 (PopART) trial
04 February 2021
•
SA19
•
12:15
>
13:45
•
Understanding and unpacking the results of the HPTN 071 (PopART) trial
•
Satellite Channel 3
The primary results of the HPTN 071 (PopART) trial were published in July 2019. They showed that the PopART universal testing and treatment (UTT) intervention achieved the UNAIDS 90-90-90 targets within three years, and reduced HIV incidence at population level by about 20%. An unexpected finding was that stronger evidence of an effect on HIV incidence was found in Arm B (where ART was initially delivered according to national guidelines) than in Arm A (where immediate ART was offered throughout the trial). In this symposium, we present a number of additional analyses that have been carried out to gain a clearer understanding of the trial results. We hope that this symposium will help to build a clearer understanding of the results of the trial and their implications.
12:15
•
SA19.01
•
Introduction: Overview of trial and results
See abstract
12:20
•
SA19.02
•
Did the PopART intervention lead to changes in sexual behavior? Were there differences in behavior between study arms?
See abstract
12:35
•
SA19.03
•
Model projections: Did the mathematical model fit the data from the trial? What was the projected impact of the intervention if sustained over time and implemented more widely?
See abstract
12:50
•
SA19.04
•
How did ART adherence and viral suppression in those on ART compare between study arms and over time? Could poor adherence explain the lower impact in Arm A?
See abstract
13:05
•
SA19.05
•
What were the community-level correlates of HIV incidence in the trial? Could differences in community viral burden explain the differences in incidence between study arms and between communities?
See abstract
13:20
•
SA19.06
•
Summary and concluding remarks
See abstract
|