Noise Exposure
22 September 2024
Noise Exposure
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S112
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10:00
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12:00
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Noise Exposure
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Dragonnier 3 – 280
Noise Exposure
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INT161
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Prevention of NIHL using investigational treatments
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C.
Colleen
LE PRELL (Dallas)
Content : Colleen Le Prell, Ph.D.
Professor and Chair, Department of Speech, Language, and Hearing
The University of Texas at Dallas, USA
Identification of biochemical pathways that drive noise-induced cell death has allowed drugs that reduce noise-induced hearing loss (NIHL) to be identified in animal models. If shown to be effective in humans, new medicines could potentially supplement hearing protection devices and more effectively prevent NIHL. However, outcomes in clinical trials have been more mixed than results in animal models. This session will review the current status of otoprotective drug development and provide practical take-home messages you can share with patients regarding both the drug discovery pipeline and dietary supplements currently sold in the absence of supporting clinical data.
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INT162
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Facilitating recovery of the afferent synapses after a noise injury
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E.
Eric
BIELEFELD (The Ohio State University)
Content : Eric Bielefeld, Ph.D.
Professor and Chair, Department of Speech and Hearing Science
The Ohio State University, USA
Cochlear synaptopathy is a significant underlying pathology of noise injury in animal models. It also serves as an explanation for some of the symptoms of noise-induced hearing loss that human clinical patients present. The synapses represent a point of vulnerability where intervention can improve outcomes, either through the preservation of synapses and spiral ganglion cell dendrites or the restoration of lost synapses. Pharmaceutical and gene therapy approaches targeting this pathway are evolving and show promise in improving the afferent pathway damaged by noise. We will review literature on this topic and transition to discussion of current work in the area.
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INT163
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Hearing Difficulties in Individuals with Normal Hearing Thresholds but Self-reported Changes in Hearing after Noise Exposure
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D.
Douglas
BRUNGART (Walter Reed National Military Medical Center)
Content : Douglas Brungart
Walter Reed National Military Medical Center, USA
Most hearing conservation programs focus on the prevention of permanent threshold shifts. Reports suggest that noise/blast-exposed individuals have hearing difficulties even with thresholds in the normal range. Our study shows that Service Members who notice hearing changes following noise exposures have systematically worse hearing difficulties then those with the same thresholds but do not notice hearing changes. High-level noise exposures may cause long-term hearing damage even when not detected as permanent threshold shifts. [The views expressed in this presentation are those of the authors and do not reflect the official policy of the Department of Defense or the US Government].
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INT164
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Noise exposures and hearing dysfunctions in professionals of cultural and creative industries
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B.
Benoit
POUYATOS (Institut National De Recherche Et Sécurité (Inrs))
Content : Benoit Pouyatos, Ph.D.
Manager, Laboratoire d'Ototoxicité et de Neurotoxicité
Institut National de Recherche et Sécurité (INRS), France
The number of cases of occupational deafness in France has declined steadily between 2007-2021. Cases however have been underestimated according to the French National Health Insurance Fund. The governing body that tracks cases does not include activities in the entertainment sector. To appraise the situation more accurately we measured noise exposure and auditory fatigue in employees of concert venues and musicians and analyzed 111,000 audiometry measurements from 63,200 workers. The prevalence of hearing loss, auditory fatigue and noise exposure data were contrasted to the number of recognized occupational deafness. Alternatives to mitigate the auditory risk in this sector are discussed.
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INT165
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Effects on work ability among women with hyperacusis and/or sound-induced auditory fatigue – markedly increased risks in communication-intensive human-service occupations
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M.
Maria
HOFF (Gothenburg)
Content : Sofie Fredriksson, Ph.D
Occupational and Environmental Medicine, School of Public Health and Community Medicine
University of Gothenburg, Sweden
Our prior research show that women who work in communication-intensive noise (e.g. in preschools) have increased risks of hearing-related symptoms. The risk is more than doubled for hyperacusis and a symptom identified as “sound-induced auditory fatigue”. Hyperacusis may trigger social avoidance, and auditory fatigue may result in withdrawal from interaction. Consequently, work ability may be negatively impacted, particularly in human-service occupations. This presentation describes an ongoing study including survey responses from nearly 5,000 women. The results indicate that hyperacusis and sound-induced auditory fatigue significantly both significantly increase the risk of poor work ability, with stronger effects in communication-intensive human-service occupations.
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